Figure 3.

PFS (A) and OS (B). PFS was calculated for the all-treated population from the start date of therapy until treatment discontinuation due to disease progression (as assessed by the investigator; including transformation to AP or BP CML) or death, or death within 30 days of the last dose; patients without events were censored at their last assessment visit. OS was calculated for the all-treated population from the start date of therapy to the date of death due to any cause; patients without events were censored at the last contact (patients were followed up for 2 years after treatment discontinuation). PFS and OS at 1 and 2 years were based on Kaplan–Meier estimates. Abbreviations: AP, accelerated phase; BP, blast phase; CML, chronic myeloid leukemia; IM-I, imatinib intolerant; IM-R, imatinib resistant; OS, overall survival; PFS, progression-free survival.