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Model of dual ZNF750 gene regulatory impacts in epidermal differentiation. ZNF750 physically interacts with KLF4, RCOR1, and CTBP1/2 to bind and activate epidermal differentiation genes. ZNF750 binds in close proximity to KLF4 DNA binding at differentiation genes. At progenitor genes, ZNF750 interacts with KDM1A, RCOR1, and CTBP1/2 to repress gene expression.
