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. 2014 Sep 15;28(18):2056–2069. doi: 10.1101/gad.246124.114

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© 2014 Mu et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — EED deficiency causes germ cell depletion. (A) RT–PCR analysis of PRC2 core components in mouse testis of different ages, tissues, embryos, and cell lines. Gapdh was used as a control. (B–I) Testis sections from P3 and P12 testes were coimmunostained with the antibodies indicated. The arrowheads, arrows, and asterisks point to spermatogonia, spermatocytes, and Sertoli cells, respectively. MVH staining marks germ cells. (J) Two-month-old testes. (K,L) Hematoxylin and eosin-stained sections of 4-wk-old testes. Arrowheads indicate pyknotic cells with condensed chromatin or fragmented nuclei. (z) A zygotene spermatocyte; (p) a pachytene spermatocyte; (r), a round spermatid; (s), a Sertoli cell. In all of the figures, Ctrl indicates control (MvhCre;Eed^fl/+), and Mut indicates Eed mutant (MvhCre;Eed^fl/Δ). Bars: B–I, 10 μm; K,L, 20 μm; J, 1 mm.