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Effect of CRY1 or PER2 nuclear entry on E-box binding and transcription in Cry1/2−/− or Per1/2−/− mutants. Nuclear entry of CRY1–ER* inhibits transcription (A) without disrupting the CLOCK–BMAL1–E-box complex (B) and is accompanied by increased binding of CRY1 to the E-box (C). Nuclear entry of PER2–ER* inhibits transcription (D) by displacing CLOCK–BMAL1 (E) and CRY1 (F) from the E-box.
