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. 2014 Sep 23;5:351. doi: 10.3389/fphys.2014.00351

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Copyright © 2014 Karunamuni, Gu, Ford, Peterson, Ma, Wang, Rollins, Jenkins and Watanabe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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E13.5 HEXIM1 mutant heart phenotyping (modified from Jenkins et al., 2007). 2-D OCT image of a semi-frontal plane of a wild-type heart (A) compared to the HEXIM1 homozygous mutant heart (B). Stereoscopic images of wildtype (C) and mutant hearts (D) indicate little blood in the left ventricle (LV) of the mutant heart. The interventricular septum (IVS) in the wildtype is present (A) but in a different orientation than in the mutant heart (B). 3-D surface rendering reconstructions from OCT images (red) of wildtype (E) and mutant (F) embryo hearts. The left atrium (LA) is smaller in the mutant than in the wild type and the left ventricle (LV) has little of no lumen, while the right ventricle (RV) lumen is enlarged. RA, right atrium; RV, right ventricle; LV, left ventricle; LA, left atrium; and IVS, interventricular septum (from Jenkins et al., 2007).