Table 1.

Nominally significant miRNAs in amygdala.

miRNA	miRBase 21 accession	RNA-Seq		Microarray
		Fold change	p-Value	Fold change	p-Value
ETHANOL EFFECT IN NON-ENRICHED RATS [ETHANOLNON-SOCIAL VS CONTROLNON-SOCIAL]
miR-1843a-3p	MIMAT0024848	−1.50	0.097	−1.62	0.045
miR-221-5p	MIMAT0017163	−1.38	0.031	−1.15	0.004
miR-29c-3p	MIMAT0000803	−1.18	0.038	−1.12	0.068
miR-384-5p	MIMAT0005309	−1.12	0.063	−1.21	0.002
miR-412-3p	MIMAT0003124	−2.57	0.025	−1.20	0.032
mir-129-1	MI0000902	−1.31	0.079	−1.27	0.089
mir-138-2	MI0000911	−1.20	0.065	−1.28	0.014
mir-155	MI0025509	1.34	0.057	1.24	0.026
mir-322-2	MI0031763	−1.23	0.064	−1.36	0.017
mir-34c	MI0000876	2.83	0.072	1.52	0.013
mir-496	MI0012622	−1.54	0.010	−1.18	0.031
mir-9a-2	MI0000840	−1.17	0.062	−1.26	0.045
miR-148a-5p	MIMAT0035724	−1.19	0.011
miR-15b-3p	MIMAT0017093	4.50	0.024
miR-221-3p	MIMAT0000890	−1.27	0.010
miR-222-3p	MIMAT0000891	−1.23	0.030
miR-299a-5p	MIMAT0000901	−1.55	0.049
miR-301b-3p	MIMAT0005304	2.85	0.017
miR-448-3p	MIMAT0001534	4.07	0.040
miR-449a-5p	MIMAT0001543	3.84	0.044
miR-495	MIMAT0005320	−1.46	0.035
miR-6329	MIMAT0025068	−2.38	0.003
miR-667-3p	MIMAT0012852	−1.30	0.017
mir-204	MI0000946	3.97	0.042
mir-299a	MI0000970	−1.46	0.007
mir-3084a	MI0030358	3.69	0.034
mir-3556b-2	MI0031769	−1.18	0.006
mir-448	MI0001639	3.59	0.050
mir-6329	MI0021853	−1.45	0.045
ETHANOL EFFECT IN SOCIALLY ENRICHED RATS [ETHANOLSOCIAL VS CONTROLSOCIAL]
mir-218a-2	MI0000957	1.33	0.054	1.22	0.029
let-7c-2	MI0000831	1.38	0.018
let-7c-5p	MIMAT0000776	1.39	0.005
miR-148a-5p	MIMAT0035724	−1.17	0.022
miR-195-5p	MIMAT0000870	1.25	0.039
miR-6319	MIMAT0025056	−11.33	0.002
miR-6324	MIMAT0025063	−25.25	0.005
miR-872-3p	MIMAT0005283	−1.39	0.002
mir-195	MI0000939	1.26	0.044
mir-6324	MI0021848	−4.38	0.008
mir-708	MI0006160	1.25	0.030
SOCIAL ENRICHMENT EFFECT IN CONTROL RATS [SOCIALCONTROL VS NON-SOCIALCONTROL]
miR-106b-5p	MIMAT0000825	−1.35	0.001	−1.39	0.008
miR-218a-5p	MIMAT0000888	−1.30	0.032	−2.15	0.010
miR-30c-5p	MIMAT0000804	−1.09	0.096	−1.39	0.002
miR-674-3p	MIMAT0005330	−1.29	0.024	−1.50	0.072
miR-96-5p	MIMAT0000818	−3.78	0.099	−1.32	0.001
miR-9a-3p	MIMAT0004708	−1.11	0.087	−1.51	1E-06
mir-218b	MI0015428	−1.31	0.036	−1.42	0.029
mir-503-2	MI0031773	−2.42	0.062	−1.46	0.001
mir-544	MI0012593	5.25	0.022	1.24	0.068
miR-106b-5p	MIMAT0000825	−1.35	0.001	−1.39	0.008
miR-218a-2-3p	MIMAT0004740	11.03	0.045
miR-221-3p	MIMAT0000890	−1.20	0.034
miR-299a-5p	MIMAT0000901	−1.57	0.044
miR-3084d	MIMAT0035745	−1.84	0.041
miR-503-3p	MIMAT0017224	−1.76	0.032
miR-6319	MIMAT0025056	2.16	0.043
miR-6329	MIMAT0025068	−1.58	0.042
miR-667-3p	MIMAT0012852	−1.34	0.009
miR-872-3p	MIMAT0005283	1.28	0.011
mir-6319-1	MI0021841	4.26	0.028
mir-708	MI0006160	−1.24	0.033
SOCIAL ENRICHMENT EFFECT IN ETHANOL RATS [SOCIALETHANOL VS NON-SOCIALETHANOL]
miR-17-1-3p	MIMAT0004710	1.75	0.058	1.21	0.008
miR-204-5p	MIMAT0000877	−2.83	0.084	−3.52	0.057
miR-376b-5p	MIMAT0003195	1.36	0.015	2.29	9.7E-07
miR-378a-5p	MIMAT0003378	−1.98	0.014	−1.38	0.002
miR-384-5p	MIMAT0005309	1.12	0.060	1.12	0.038
miR-874-5p	MIMAT0017290	−1.91	0.047	−1.28	0.041
mir-19a	MI0000849	−1.88	0.079	−1.25	0.085
miR-142-3p	MIMAT0000848	−2.53	0.013
miR-183-5p	MIMAT0000860	−358.64	0.049
miR-199a-3p	MIMAT0004738	−1.51	0.027
miR-222-3p	MIMAT0000891	1.21	0.049
miR-301b-3p	MIMAT0005304	−2.21	0.041
miR-3068-5p	MIMAT0024845	1.47	0.013
miR-3557-3p	MIMAT0017820	−1.98	0.014
miR-379-3p	MIMAT0004791	1.31	0.019
miR-493-3p	MIMAT0003191	−2.80	0.050
miR-6329	MIMAT0025068	1.84	0.049
mir-296	MI0000967	1.45	0.034
mir-299a	MI0000970	1.41	0.015

Comparisons and fold changes measured using RNA-Seq and, where available, validated by Microarray quantification. Table contains miRNAs with consistent changes at an uncorrected p-value cutoff of 0.1 or less for both RNA-Seq and Microarray data sets, or miRNAs that were not present on the array but were observed to change in the RNA-Seq data with an uncorrected p-value cutoff of 0.05 or less.