Table 3.

Clinical response at week 24* among golimumab+ MTX-treated patients^† by number of previous TNF inhibitor(s)

	Number of previous TNF inhibitor(s)
	1 TNF inhibitor	2 TNF inhibitors	3 TNF inhibitors
Patients who discontinued one or more previous TNF-inhibitor for any reason, n	137	47	17
ACR20 response	61 (44.5%)	17 (36.2%)	4 (23.5%)
ACR50 response	30 (21.9%)	11 (23.4%)	1 (5.9%)
DAS28 response (good/moderate)
DAS28-CRP	80 (58.4%)	24 (51.1%)	10 (58.8%)
DAS28-ESR	82 (59.9%)	24 (51.1%)	10 (58.8%)
DAS28 score <2.6
DAS28-CRP	22 (16.1%)	3 (6.4%)	1 (5.9%)
DAS28-ESR	23 (16.8%)	3 (6.4%)	1 (5.9%)
HAQ-DI ≥0.25-unit improvement	73 (53.3%)	22 (46.8%)	7 (41.2%)

Data presented are number (%) of patients unless otherwise noted.

*For patients who escaped early, efficacy data from week 16 were carried forward for analysis at week 24.

^†Excludes patients from a single site due to violations at the study site identified during the Sponsor's standard audit processes.

ACR20, ACR50, at least 20% or 50% improvement according to the American College of Rheumatology response criteria; CRP, C reactive protein; DAS28, 28-joint Disease Activity Score; ESR, erythrocyte sedimentation rate; HAQ-DI, Health Assessment Questionnaire Disability Index; MTX, methotrexate; TNF, tumour necrosis factor.