Figure 5.

Representative images of the scanning region under various conditions.

Notes: (A) After ~5 minutes post-FUS at the dose of acoustic power density 13.1 W/cm² (voltage =4 V, BRR =500 kHz) with MB injection. (B) After ~20 minutes post-FUS at a lower dose of 6.3 W/cm² (voltage =2.5 V, BRR =500 kHz) with MB injection. (C) After ~20 minutes post-FUS at the same lower dose of 6.3 W/cm², but reduced voltage =1.25 V and increased BRR =1,000 kHz, with MB injection. (D) Under control condition, with neither ultrasound sonication nor MB injection.

Abbreviations: BRR, burst repetition rate; FUS, focused ultrasound; MB, microbubble.