FIG 2 .

Serum bactericidal antibody responses of Tg and WT mice immunized with the 4CMenB vaccine. Symbols are the same as in Fig. 1. Strain SK016 (A, B) was mismatched for each of the antigens in the 4CMenB vaccine, except PorA P1.4. Strain 5/99 (C, D) was mismatched for each of the antigens except NadA, and strain H44/76 (E, F) was mismatched for each of the antigens except FHbp. (A, C, E) Data from a representative experiment showing the percent survival values of the different test strains after incubation for 1 h at 37°C with 20% human complement and different dilutions of serum pools from 4CMenB-vaccinated Tg or WT mice. Results for each strain were replicated in two or three independent experiments. (B, D, F) Reciprocal serum bactericidal antibody titers of individual Tg or WT mice. There were no significant differences between the respective GMTs (horizontal lines) of 4CMenB-vaccinated Tg or WT mice against strain SK016 (B) (P = 0.19) or strain 5/99 (D) (P = 0.21). Tg mice had lower titers of antibody against H44/76 than WT mice did (F) (P = 0.0006).