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Serum IgM antibody reactivity with human FH as measured by ELISA. (A) IgM reactivity of 1:100 dilutions of serum samples from individual human FH Tg mice immunized with three doses of 4CMenB vaccine. The bars represent median values of duplicate or triplicate measurements, and error bars represent the ranges. (B) IgM reactivity to human FH in representative serum samples tested at different dilutions. The respective results were replicated in four independent experiments.
