Table 2.
Biomarker concentration stratified by renal recovery and mortality
| Biomarker | Median (IQR) |
|||
|---|---|---|---|---|
| Recovery | Nonrecovery | Survivors | Nonsurvivors | |
| Inflammation | ||||
| IL-6 | 114 (56.6–272) | 197 (91.6–710)** | 124 (56.6–280) | 230 (103–911)** |
| IL-8 | 69.5 (36–166) | 128 (57.3–393)** | 71.5 (35.8–164) | 146 (63–505)** |
| IL-10 | 13.3 (6–31.4) | 17.9 (8.2–44.3)** | 13.4 (6.2–29.5) | 19.2 (8.5–56)** |
| IL-18 | 87.9 (39.1–157) | 118 (50.7–238)** | 86.6 (39.3–155) | 127 (52.7–254)** |
| IL-1βa | 22.7 (22.7–34.3) | 22.7 (22.7–45.7) | 22.7 (22.7–32.6) | 22.7 (22.7–47.9)** |
| MIF | 196 (78.8–540) | 298 (106–891)** | 184 (70.7–531) | 337 (139–1003)** |
| TNFa | 2.4 (2.4–3.7) | 2.4 (2.4–3.4) | 2.4 (2.4–3.6) | 2.4 (2.4–3.5) |
| Apoptosis | ||||
| TNFR-I | 11 919 (8294–15 958) | 13 698 (10 167–18 805)** | 12 173 (8630–16 247) | 13 779 (10 312–19 147)** |
| TNFR-II | 5179 (3939–7194) | 5700 (4254–7775)* | 5285 (4005–7217) | 5729 (4300–8084)* |
| DR-5 | 201 (120–370) | 240 (147–417)** | 200 (120–357) | 261 (154–448)** |
| Growth factor | ||||
| GM-CSFa | 8.5 (3.1–20.6) | 8.8 (3.1–20) | 7.9 (3.1–19) | 9.4 (3.9–21.6) |
a25.3% of GM-CSF values, 62.7% of IL-1β and 63.7% of TNF values were below the detection thresholds and were censored.
*P < 0.05; **P < 0.01.
IQR, interquartile range. Median biomarker concentrations are expressed in picograms/milliliter. All biomarkers were measured in 817 subjects except DR-5, which was measured in 816 subjects.