TABLE 1.

Clinical manifestations of human parechovirus (HPeV) according to type

HPeV type	Clinical features*
1	Asymptomatic infection (2); acute flaccid paralysis (3), meningitis and encephalitis (4); coryza and pneumonia (5); acute otitis media (6); myocarditis (7); severe dilated cardiomyopathy (8); diarrhea (9,10) including bloody diarrhea (11); necrotizing enterocolitis (12); hemolytic uremic syndrome (13); lymphadenopathy (14); Reye’s syndrome (11); uveitis† (15)
2	Mild gastrointestinal symptoms (1); mild respiratory symptoms (1); uveitis† (15)
3	Infant sepsis (16,17); infant meningitis (18,19), encephalitis (20), and transient paralysis (21); diarrhea (9,10); palmer-planter erythematous rash and maculopapular rash (18); neonatal hemorrhage-hepatitis syndrome (22); hemophagocytic lymphohistiocytosis-like syndrome (23); myalgia† (24); uveitis (15); sudden infant death syndrome (25,26)
4	Infant central nervous system disease (27); lymphadenitis (9,28); infant fever (28) and sepsis (29); gastroenteritis (10)
5	Diarrhea (9,10); acute flaccid paralysis (28)
6	Diarrhea (9); acute flaccid paralysis (3); Reye’s syndrome (30);
7	Acute flaccid paralysis (3)
8	Gastroenteritis (31)
9	Unpublished
10	Gastroenteritis (10,32,33)
11	Diarrhea (10)
12	Diarrhea with acute flaccid paralysis (34)
13	Gastroenteritis (32)
14	Diarrhea (9); fever (32)
15	Diarrhea (32)
16	Unpublished

^*These clinical features have been described in at least one patient shedding HPeV but there may be no relationship between HPeV and these signs or symptoms;

^†These clinical features have only been described in adults to date