Fig. 4.

Effect of alirocumab, atorvastatin, and their combination on atherosclerosis development in aortic root and arch. After 18 weeks of treatment, the total lesion area per cross-section was assessed (A). The total plaque load in the aortic arch was analyzed after Oil Red O staining (B). Lesion severity was assessed and categorized as no lesions, mild lesions (type I–III), and severe (type IV–V) lesions (C). Data are expressed as percentage of the stained area. * P < 0.05, *** P < 0.001 as compared with control; † P < 0.05, †† P < 0.01, ††† P < 0.001 as compared with atorvastatin; ‡ P < 0.05, ‡‡ P < 0.01 for 3 mg/kg alirocumab compared with 10 mg/kg alirocumab (n = 15 per group in the root area and n = 6–7 in the arch).