TABLE 1.
Metabolite set enrichment analysis in 3T3-L1 preadipocytes and differentiated adipocytes
| Pathways (8) | Metabolites (33) | Total | Q Statistic | Raw P Value | Holm P Valuea | FDRa |
| CYP epoxygenase-derived arachidonic acid metabolites | 8,9-EET, 11,12-EET, 14,15-EET, 5,6-DHET, 8,9-DHET, 11,12-DHET, 14,15-DHET | 7 | 86.60 | 1.69E-16 | 1.35E-15 | 1.35E-15 |
| CYP epoxygenase-derived linoleic acid metabolites | 9,10-EpOME, 12,13-EpOME, 9,10-DiHOME, 12,13-DiHOME | 4 | 85.07 | 3.61E-15 | 2.53E-14 | 1.47E-14 |
| Lipoxygenase-derived arachidonic acid metabolites | 15-HETE, 12-HETE, 11-HETE, 8-HETE, 5-HETE | 5 | 84.86 | 7.39E-14 | 4.43E-13 | 1.97E-13 |
| Lipoxygenase-derived linoleic acid metabolites | 9,12,13-TriHOME, 9,10,13-TriHOME, 13-HODE, 9-HODE | 4 | 37.21 | 1.50E-05 | 7.49E-05 | 2.99E-05 |
| CYP hydroxylase-derived arachidonic acid metabolites | 19-HETE, 20-HETE | 2 | 41.72 | 5.82E-05 | 2.33E-04 | 9.31E-05 |
| Cyclooxygenase-derived arachidonic acid metabolites | 6-keto-PGF1α, TxB2, PGF2α, PGD2, PGE2, 8-iso-PGF2α, PGB2 | 7 | 21.53 | 5.46E-04 | 1.64E-03 | 7.28E-04 |
| CYP epoxygenase-derived docosahexaenoic acid metabolites | 19,20-DiHDPA, 19,20-EpDPE | 2 | 14.93 | 0.029 | 0.058 | 0.033 |
| CYP epoxygenase-derived eicosapentaenoic acid metabolites | 17,18-DiHETE, 17,18-EpETE | 2 | 1.94 | 0.447 | 0.447 | 0.447 |
DiHDPA, dihydroxydocosapentaenoic acid; DiHETE, dihydroxyeicosatetraenoic acid; DiHOME, dihydroxyoctadecenoic acid; EpDPE, epoxydocosapentaenoic acid; EpETE, epoxyeicosatetraenoic acid; EpOME, epoxyoctadecenoic acid; PG, prostaglandin; TriHOME, trihydroxyoctadecenoic acid; Tx, thromboxane.
a
The pathways (rank-ordered) were considered significantly enriched when the Holm P < 6.25E-03 and FDR <5%.