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. 2014 Sep 24;6:258. doi: 10.3389/fnagi.2014.00258

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Copyright © 2014 Charron, Doudnikoff, Canron, Li, Véga, Marais, Baufreton, Vital, Oliet and Bezard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Astrocytes further contacts asymmetric striatal synapses after dopamine depletion. (A) Electron micrograph of GLT1 immunolabeled striatal astrocytes colored in green (pseudocolor image NHI Image J) (scale bar = 2 μm). (B) GLT1-positive astrocytic processes surrounding (asterisk) or not surrounding asymmetric striatal synapses (arrowhead) (scale bar = 0.5 μm). (C) A significant decrease in the number of asymmetric synapses is observed in 6-OHDA rat striatum compared with control (n = 4 animals per group; Student t-test; p < 0.05). (D) Such decrease however decomposes in a significant increase in GLT1+ asymmetric synapses and a dramatic decrease in the number of GLT1− asymmetric synapses in the 6-OHDA rat compared to controls (n = 4 animals per group; one-way ANOVA followed by Bonferroni; p < 0.05).