Table 2.
In vivo characteristics of the different formulations
| Formulations | AUC0-∞ (μg min/mL) | Cmax (μg/mL) | Tmax (min) |
|---|---|---|---|
| Pure MBZ | 36.043±8.867 | 0.052±0.014 | 78.75±22.5 |
| Recrystallized MBZ | 30.542±5.896 | 0.073±0.009 | 67.50±24.65 |
| RDM-1:1 | 71.476±14.498 | 0.113±0.029 | 75.00±23.24 |
| RDM-1:2.5 | 96.380±28.808 | 0.324±0.018 | 42.50±6.12 |
| RDM-1:5 | 106.964±28.039 | 0.226±0.044 | 60.00±23.24 |
Abbreviations: AUC, area(s) under the curve; MBZ, mebendazole; RDM, redispersible microparticles; Cmax, maximum plasma concentration; Tmax, time taken to achieve Cmax; min, minutes.