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. 2013 Sep 26;69(10):910–917. doi: 10.1136/thoraxjnl-2013-204023

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Relationship between pulmonary function at 3 months and 1 year in newborn screened CF infants. The 95% limits of ‘normal range’ (97.5th centile for Lung Clearance Index (LCI) and functional residual capacity (FRC) and 2.5th centile for FEV_0.5) are represented by vertical dashed lines at 3 months (3m) and horizontal lines at 1 year (1yr). Those with normal pulmonary function tests on both occasions fall within the lower left quadrant for LCI and FRC, and upper right quadrant for FEV_0.5. Infants with abnormal LCI at 3 months but normal LCI at a year, lie within the lower right quadrant (A), while those with abnormal FEV_0.5 at 3 months which has normalised by 1 year are within the left upper quadrant of (C).