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. 2014 Aug 13;8(9):8776–8785. doi: 10.1021/nn501129q

Figure 5.

Figure 5

In vivo therapeutic efficacy of nanoSTATs. (a) Quantification of fibrin deposited in the lungs of mice dosed with thromboplastin (T, 2 μL/g body weight) and nanoSTATs (nS, 200 U/kg) or free heparin (Hep, 200 U/kg) (**p < 0.01 by one-way ANOVA with Tukey post test; n = 5 mice, SE). (b) Near-infrared fluorescent scans of excised lungs to assess VT750-labeled fibrinogen following intravenous injection of PBS, T only, T + nS, and T + Hep. (c) H&E staining of lungs in mice under the same conditions as in (b). Arrow denotes fibrin clots; arrowheads denote patent vessels (scale bar = 100 μm).