Table 3.

Cox regression analysis, overall survival (n = 560 in the multiple analysis)

	Simple analysis			Multiple analysis
	HR	95% CI	p-value	HR	95% CI	p-value
Sex
Female	1			1
Male	1.41	1.08-1.84	0.01	1.68	1.28-2.19	0.0002
Age, median 74
<74	1			1
≥74	2.39	1.80-3.16	<0.0001	2.58	1.94-3.42	<0.0001
T category
T3	1			1
T4	1.99	1.43-2.78	0.0001	1.76	1.24-2.49	0.002
Malignancy grade
Medium + Low	1
High*	1.22	0.88-1.69	0.24
Localisation
Right	1
Left	0.96	0.73-1.24	0.74
Perforation
No	1			1
Yes	1.80	1.20-2.72	0.005	1.49	0.96-2.32	0.08
Fixation
No	1			1
Yes	1.60	1.17-2.18	0.004	1.26	0.89-1.78	0.20
Lymph nodes
≥12	1
<12	1.06	0.82-1.39	0.64
Neuronal invasion
No	1
Yes	1.19	0.76-1.87	0.44
Vascular invasion
No	1			1
Yes	1.60	1.12-2.30	0.01	1.47	1.02-2.11	0.04
MSI status
MSI	1
MSS	0.92	0.69-1.24	0.59
miRNA-126
<median	1			1
>median	0.75	0.57-0.98	0.03	0.76	0.58-1.00	0.051
MVD
<median	1
>median	1.01	0.77-1.32	0.94

HR: hazard ratio; CI: confidence interval; MSI: microsatellite instability; MSS: microsatelite stable; miRNA-126: microRNA-126; MVD: microvessel density.

*Including mucinous and sigillocellular adenocarcinomas.

Significant p-values are highlighted in bold.