Table 2.
The log-transformed means, standard deviations, and ranges of total skin NKA level [ln(ng/μg keratin)] and urine biomarker levels [ln(μg/L)] as well as the associations between these biomarker levels and the specific genotypes in the fuel-cell maintenance workers exposed to jet fuel.
Prevalence (%) | Total NKA | 1-naphthol | 2-naphthol | Total naphthols | Naphthalene | Total urine biomarkers* | |
---|---|---|---|---|---|---|---|
Average | 1.03 | 9.58 | 9.96 | 10.54 | 5.4 | 10.56 | |
STD | 0.38 | 1.19 | 1.17 | 1.13 | 2.21 | 1.14 | |
Range | 0.24–2.04 | 6.18–11.31 | 6.18–12.49 | 6.88–12.53 | −0.84–10.59 | 6.89–12.53 | |
Association: | |||||||
CYP2E1*6 | |||||||
DD | 88/105 (84) | 1.04 | 9.55 | 9.94 | 10.52 | 5.29 | 10.55 |
CD | 14/105 (13) | 0.91 | 9.78 | 10.07 | 10.65 | 6.13 | 10.67 |
CC | 3/105 (3) | 1.18 | 9.63 | 10.03 | 10.54 | 5.26 | 10.56 |
GSTM1-null | 63/105 (60) | 1.03 | 9.52 | 9.94 | 10.5 | 5.13 | 10.52 |
GSTM1-plus (++/+−) | 42/105 (40) | 1.03 | 9.68 | 10 | 10.6 | 5.82 | 10.64 |
GSTT1-null | 24/105 (23) | 0.91a | 9.81 | 9.99 | 10.64 | 5.88 | 10.65 |
GSTT1-plus (++/+−) | 81/105 (77) | 1.06 | 9.51 | 9.96 | 10.51 | 5.26 | 10.54 |
NQO1 | |||||||
CC | 66/105 (63) | 1.06 | 9.75 | 10.08 | 10.69 | 5.6 | 10.71 |
CT | 34/105 (32) | 1 | 9.25 | 9.75 | 10.26 | 4.87 | 10.28 |
TT | 5/105 (5) | 0.69b | 9.68 | 9.97 | 10.56 | 6.43 | 10.578 |
The log-transformed sum of urine naphthalene, 1NAP, and 2NAP levels;
Significant difference (p = 0.080) from the mean level in the GSTT1-plus group;
Significant difference (p = 0.085) from the mean level in the NQO1 (CC) type.