The effects of nicotine (a,b), epibatidine (c,d), varenicline (e,f), cytisine (g,h) or saline (same saline control data re-plotted in each graph) on MAP (a,c,e,g) and heart rate (b,d,f,h) in conscious, freely-moving rats. Data are presented as percent change over resting baseline for each subject and then averaged (± standard error of the mean (sem)) from 6-7 rats per treatment condition. The dotted line indicates the average resting MAP or heart rate (100%) for all rats.