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Area under the curve (± SEM) over resting baseline for antagonists mecamylamine-, DHbE-, hexamethonium-, and MLA-induced changes in MAP (0-60 min) or HR (0-30 min)
| Treatment | MAP | HR
|
|
|---|---|---|---|
| 0-30 min | |||
|
| |||
| saline | 167.9 (259) | 429 (133) | |
|
| |||
| mecamylamine (mg/kg) | 1 | 222 (51) | 724 (73) |
| 3.2 | -467 (95)* | 551 (73) | |
|
| |||
| DHβE (mg/kg) | 5.6 | 474 (175) | 273 (72) |
| 10 | 762 (92) | 580 (97) | |
|
| |||
| hexamethonium (mg/kg) | 3.2 | 345 (113) | 953 (164) |
| 10 | -258 (164) | 662 (136) | |
|
| |||
| MLA (mg/kg) | 10 | 687 (111) | 410 (55) |
p<0.05 vs saline
