Table 5.

Prognostic performance of biomarkers and ICU scores for 30-day and 6-month all-cause mortality during the first week of ICU treatment

	Presepsin	Interleukin-6	Procalcitonin	C-reactive protein	Leukocytes	SOFA	APACHE II
	AUC (95% CI)
30-day all-cause mortality
Day 1	0.64	0.69	0.59	0.54	0.51	0.64	0.70
	(0.54, 0.75)	(0.55, 0.76)	(0.48, 0.69)	(0.43, 0.65)	(0.41, 0.62)	(0.52, 0.77)	(0.60, 0.80)
	P  = 0.008	P  = 0.001	P = 0.1	P = 0.5	P = 0.8	P  = 0.05	P  = 0.0001
Day 3	0.70	0.69	0.58	0.64	0.55	0.65	0.64
	(0.59, 0.81)	(0.58, 0.80)	(0.46, 0.70)	(0.52, 0.76)	(0.42, 0.67)	(0.53, 0.77)	(0.51, 0.77)
	P  = 0.002	P  = 0.002	P = 0.2	P = 0.03	P = 0.5	P  = 0.04	P  = 0.04
Day 8	0.69	0.67	0.57	0.61	0.60	0.69	0.60
	(0.56, 0.82)	(0.54, 0.81)	(0.41, 0.73)	(0.46, 0.75)	(0.46, 0.75)	(0.57, 0.81)	(0.42, 0.78)
	P  = 0.02	P  = 0.03	P = 0.4	P = 0.2	P = 0.2	P  = 0.007	P = 0.3
58 of 116 patients died after 30 days corresponding to a 50% all-cause mortality rate.
6 months all-cause mortality
Day 1	0.68	0.66	0.59	0.57	0.54	0.67	0.65
	(0.58, 0.78)	(0.56, 0.76)	(0.49, 0.70)	(0.45, 0.69)	(0.43, 0.65)	(0.55, 0.78)	(0.54, 0.76)
	P  = 0.001	P = 0.05	P = 0.1	P = 0.2	P = 0.5	P  = 0.01	P  = 0.01
Day 3	0.70	0.70	0.57	0.61	0.59	0.64	0.61
	(0.59, 0.80)	(0.59, 0.80)	(0.45, 0.69)	(0.49, 0.73)	(0.47, 0.71)	(0.52, 0.76)	(0.48, 0.74)
	P  = 0.002	P  = 0.001	P = 0.3	P = 0.08	P = 0.2	P  = 0.04	P = 0.1
Day 8	0.71	0.67	0.56	0.63	0.60	0.71	0.64
	(0.58, 0.83)	(0.54, 0.80)	(0.42, 0.70)	(0.49, 0.77)	(0.46, 0.74)	(0.60, 0.83)	(0.44, 0.84)
	P  = 0.004	P  = 0.02	P = 0.4	P = 0.06	P = 0.2	P  = 0.001	P = 0.2
72 of 116 patients died after 6 months corresponding to a 62% all-cause mortality rate.

Significant P-values (P <0.05) are highlighted in bold type. AUC, area under the curve; APACHE II, acute physiology and chronic health evaluation II; SOFA, sequential organ failure assessment.