Table 6.

Cox regression models to predict 30-day and 6-month all-cause mortality at days 1, 3 and 8 of intensive care treatment

	Model 1				Model 2
	Unadjusted				Adjusted for age, sex, creatinine, ICU days, APACHE II
Predictor	HR	95% CI	Chi-square	P -value	HR	95% CI	Chi-square	P -value
All-cause mortality 30 days
Day 1
Log presepsin, pg/ml	1.9	1.2, 3.0	6.9	0.009	2.2	1.2, 4.1	42.9	0.02
Log interleukin 6, pg/ml	1.7	1.4, 2.2	20.5	0.0001	1.9	1.4, 2.7	54.7	0.0001
Day 3
Log presepsin, pg/ml	1.8	1.0, 3.3	3.7	0.05	1.3	0.5, 3.3	4.9	0.7
Log interleukin 6, pg/ml	2.6	1.6, 4.4	13.2	0.0001	3.2	2.0, 5.4	28.3	0.0001
Day 8
Log presepsin, pg/ml	2.5	1.3, 5.0	7.4	0.007	7.5	2.4, 23.3	22.6	0.001
Log interleukin 6, pg/ml	3.9	1.6, 9.4	9.2	0.003	6.0	1.9, 19.2	18.3	0.002
All-cause mortality 6 months
Day 1
Log presepsin, pg/ml	2.0	1.3, 3.0	10.6	0.001	2.7	1.5, 4.9	32.0	0.001
Log interleukin 6, pg/ml	1.7	1.3, 2.1	19.3	0.0001	1.7	1.3, 2.3	36.5	0.0001
Day 3
Log presepsin, pg/ml	1.9	1.2, 3.2	6.5	0.01	1.5	0.6, 3.4	3.3	0.4
Log interleukin 6, pg/ml	2.7	1.7, 4.3	16.6	0.0001	3.1	1.9, 4.9	22.3	0.0001
Day 8
Log presepsin, pg/ml	2.6	1.5, 4.3	12.7	0.0001	4.5	2.0, 10.4	17.2	0.0001
Log interleukin 6, pg/ml	3.1	1.6, 6.1	11.5	0.001	3.5	1.5, 7.8	12.3	0.003

Hazard ratios (HR) describe the HR for a biomarker change per log unit-increase. APACHE II, acute physiology and chronic health evaluation II score.