Extended Data Figure 3. Dimeric receptor association and interactions with cholesterols in the crystals of P2Y₁₂R.

a, Two P2Y₁₂R molecules make contact with each other, as mediated by helix V and two molecules of cholesterol related by a two-fold axis. a, b, The detailed interactions of the cholesterol molecules on helices III and V are shown in surface (b) and in cartoon (c) representations. The cholesterol molecule is coloured in yellow carbons, and P2Y₁₂R is shown in pale green (surface) or grey (cartoon). Residues within 4 Å of cholesterols are represented as green sticks. Hydrogen-bond interactions are indicated by dashed lines. As the interactions of the two cholesterols at the interface are identical, only one is revealed in detail. d, e, The binding site of cholesterol between helices I and VII is shown in surface (d) and in cartoon (e) representation. AZD1283 is shown in magenta carbons.