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Overview of indications for approved targeted therapies against EGFR and HER-2.
| Cancer Type | EGFR expression | HER-2 expression | Approved Targeted Therapy |
|---|---|---|---|
| Breast Cancer | Yes | Yes | Lapatinib, trastuzumab, pertuzumab, T-DM1 |
| Colorectal Cancer | Yes | Yes | Cetuximab, panitumumab |
| Gastric Cancer (GEJ) | No | Yes | Trastuzumab |
| HNSCC | Yes | No | Cetuximab |
| NSCLC | Yes | No | Afatinib, Erlotinib, Gefitinib |
| Pancreatic Cancer | Yes | Yes | Erlotinib |
