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. Author manuscript; available in PMC: 2015 Jun 19.
Published in final edited form as: Chem Biol. 2014 May 8;21(6):792–801. doi: 10.1016/j.chembiol.2014.03.012

Figure 6. Dormacy, Self-Seeding, and Reseeding.

Figure 6

(A and B) Workflow of photoswitching of CTCs in a tail vein (A) and monitoring CTCs in the green and red channels (B); the white arrows indicate the signals from a partly switched CTC.

(C) Combined, transmission and fluorescence, image of the dormant cell in liver (day 9 after CTC photoswitching); the red fluorescence of the dormant cell is 18-fold higher than the autofluorescence of an intact liver.

(D and E) Combined images from the green and red fluorescence channels of self-seeding (D) and reseeding (E) cells with a 48-fold and 77-fold, respectively, increase of red fluorescence compared to a green primary tumor or existing metastasis; visible vessels indicated by white dotted lines.

See also Figures S2 and S6.