Table 4.
Univariate and multivariable Cox regression models predicting cancer-specific survival in 253 patients treated with radical nephroureterectomy and ipsilateral bladder cuff for upper tract urothelial carcinoma
| Univariate |
Multivariable |
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Age | 1.03 | 1.00-1.06 | 0.02 | - | - | - |
|
| ||||||
| Gender | ||||||
| Male | Reference | - | - | - | - | - |
| Female | 0.84 | 0.46-1.53 | 0.57 | - | - | - |
|
| ||||||
| Previous bladder tumor |
1.11 | 0.62-2.00 | 0.71 | - | - | - |
|
| ||||||
| Tumor focality | ||||||
| Unifocal | Reference | - | - | - | - | - |
| Multifocal | 0.92 | 0.47-1.80 | 0.81 | - | - | - |
|
| ||||||
| Concomitant CIS | 1.65 | 0.91-2.99 | 0.09 | - | - | - |
|
| ||||||
| Postoperative chemotherapy |
4.56 | 2.03-10.2 | <0.0001 | 0.77 | 0.29-1.99 | 0.59 |
|
| ||||||
| Tumor location | ||||||
| Renal pelvis | Reference | - | - | Reference | - | - |
| Ureter | 1.38 | 0.77-2.48 | 0.27 | 1.30 | 0.72-2.37 | 0.33 |
|
| ||||||
| Tumor grade | ||||||
| Low | Reference | - | - | Reference | - | - |
| High | 3.09 | 1.31-7.29 | 0.01 | 1.92 | 0.76-4.80 | 0.16 |
|
| ||||||
| pT classification | ||||||
| pT0/pTis/pTa/pT1 | Reference | - | - | Reference | - | - |
| pT2 | 4.17 | 1.61-10.7 | 0.003 | 3.43 | 1.31-8.98 | 0.01 |
| pT3/pT4 | 11.6 | 5.10-26.5 | <0.0001 | 7.38 | 3.04-17.9 | <0.0001 |
|
| ||||||
| pN classification | ||||||
| Nx | Reference | - | - | Reference | - | - |
| NO | 1.29 | 0.64-2.62 | 0.46 | 0.90 | 0.43-1.88 | 0.78 |
| N+ | 10.4 | 4.80-22.5 | <0.0001 | 2.95 | 1.24-7.03 | 0.01 |
HR = hazard ratio; CI = confidence interval; CIS = carcinoma in situ.