Table 2.
CHD and CVD event rates per 1000 person-years and 5-year NNT for each of the polypill studies. The NNTs were calculated directly as the reciprocal of the absolute risk difference at the median follow up of 7.6 years and subsequently adjusted to a 5-year period.
| TIPS | Poly-Iran | Wald | PILL Collaboration | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAC = 0 | CAC 1-100 | CAC >100 | CAC = 0 | CAC 1-100 | CAC >100 | CAC = 0 | CAC: 1-100 | CAC >100 | CAC = 0 | CAC 1-100 | CAC >100 | |
| N (%) | 1312 (58.6%) | 581 (26%) | 345 (15.4%) | 1241 (54.5%) | 628 (27.6%) | 409 (17.9%) | 1718 (38.9%) | 1324 (30%) | 1374 (31.1%) | 1596 (40.8%) | 1161 (29.7%) | 1154 (29.5%) |
| CHD events(%) | 11 (0.8%) | 19 (3.3%) | 31 (9.0%) | 12 (1.0%) | 18 (2.9%) | 33 (8.1%) | 23 (1.3%) | 46 (3.5%) | 106 (7.7%) | 19 (1.2%) | 44 (3.8%) | 96 (8.3%) |
| CHD event rate (1000 pr-yrs) | 1.2 | 4.6 | 13.3 | 1.3 | 4.1 | 12.0 | 1.9 | 5.1 | 11.6 | 1.7 | 5.5 | 12.5 |
| CVD events(%) | 23 (1.8%) | 25 (4.3%) | 42 (12.2%) | 22 (1.8%) | 26 (4.1%) | 43 (10.5%) | 45 (2.6%) | 75 (5.7%) | 148 (10.8%) | 45 (2.8%) | 67 (5.8%) | 130 (11.3%) |
| CVD event rate (1000 pr-yrs) | 2.5 | 6.1 | 18.4 | 2.5 | 6.0 | 15.8 | 3.7 | 8.3 | 16.5 | 4.0 | 8.5 | 17.2 |