Table 3.

Hazard ratio for the presence of Coronary Artery Calcium (CAC). The results are adjusted for age, gender, race, education and MESA site

	TIPS		Poly-Iran		Wald		PILL Collaboration
	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)
CHD
CAC = 0	1 (ref)	-	1 (ref)	-	1 (ref)	-	1 (ref)	-
CAC 1 - 100	2.7 (1.2 – 5.8)	0.014	2.4 (1.1 – 5.1)	0.022	2.3 (1.4 – 3.8)	0.002	2.8 (1.6 – 4.8)	<0.0001
CAC > 100	6.4 (2.9 – 13.8)	<0.0001	5.9 (2.8 – 12.2)	<0.0001	4.7 (2.9 – 7.6)	<0.0001	5.6 (3.3 – 9.5)	<0.0001
CVD
CAC = 0	1 (ref)	-	1 (ref)	-	1 (ref)	-	1 (ref)	-
CAC 1 - 100	1.7 (0.9 – 3.1)	0.076	1.9 (1.1 – 3.4)	0.031	1.9 (1.3 – 2.7)	0.001	1.8 (1.2 – 2.7)	0.002
CAC > 100	4.4 (2.4 – 7.8)	<0.0001	4.2 (2.4 – 7.4)	<0.0001	3.3 (2.3 – 4.7)	<0.0001	3.3 (2.3 – 4.8)	<0.0001