FIG. 8.

SOD3 silencing impairs APC-induced reparative vascularization in a mouse model of limb ischemia. (A) Line graphs showing blood flow recovery from unilateral limb ischemia in mice given vehicle, scramble-transfected APCs, or SOD3-silenced APCs. Control (scramble-transfected) APCs improve blood flow recovery compared with vehicle or SOD3-silenced APCs (n=9 animals per group). (B, C) Representative pictures and bar graphs show increased capillary density in muscles injected with scramble-transfected APCs compared with vehicle or SOD3-silenced APCs at 14 days after ischemia. Values are mean±SEM (n=7 animals per group), **p<0.01 SOD3 versus scramble group; ^##p<0.01 versus Vehicle. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars