Combination of bendamustine and entinostat significantly promotes MM cells undergoing apoptosis. MM cells were cultured with RPMI1640 (0.5% FBS) in the absence or presence of either entinostat (Ent) or bendamustine (Benda) alone, or the combinations of entinostat and bendamustine for 24 h. Cells were collected and subjected to apoptotic ELISA (A) or western blot analyses with specific antibody directed against PARP, caspase-8 (Casp-8), caspase-3 (Casp-3), or β-actin (B, C, D). Bars, SD. P values vs bendamustine single agent.