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. 2014 Sep 24;9(9):e107746. doi: 10.1371/journal.pone.0107746

Table 2. Top 10 up- and down-regulated genes in the torpid brains.

Gene Symbol Description Average FPKM (Torpor) Average FPKM (Active) F.D.R
Up-regulated genes in torpid brain HSPA8 Heat shock 70 kDa protein 8 1344.595 300.3264 3.89E-202
SNAP25 Synaptosomal-associated protein, 25 kDa 862.1088 101.904 1.98E-184
CALM1 Calmodulin 991.6896 318.3168 9.56E-109
CDR1 Cerebellar degeneration-related antigen 1 337.44 11.1648 7.29E-100
HSP90AA1 Heat shock protein HSP 90-alpha 444.6336 63.984 1.58E-87
CPE Carboxypeptidase E 476.5056 91.2192 1.95E-80
SYT1 Synaptotagmin-1 292.0512 29.4048 5.18E-67
SPARCL1 SPARC-like protein 1 253.056 20.9856 2.32E-62
RPS24 40S ribosomal protein S24 432.9888 117.6096 1.51E-56
CAMK2N1 Calcium/calmodulin-dependent protein kinase II inhibitor 1 463.248 144.192 1.41E-53
Down-regulated genes in torpid brain CKB Creatine kinase, brain 207.0912 1240.042 4.77E-154
ALDOA Aldolase A, fructose-bisphosphate 427.1424 1679.405 1.07E-142
ALDOC Aldolase C, fructose-bisphosphate 491.472 1656.365 1.54E-116
TUBA1B Tubulin, alpha 1b 510.6336 1607.155 1.16E-102
MBP Myelin basic protein 71.7408 613.7568 3.01E-95
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 184.368 874.7904 1.13E-90
NDRG2 N-myc downstream-regulated gene 2 protein 177.744 797.7216 9.42E-79
APOE Apolipoprotein E 377.4912 1187.52 2.78E-76
RPS28 40S ribosomal protein S28 181.6128 770.9184 4.17E-72
TUBA4A Tubulin alpha-4A chain 179.5488 760.1952 9.34E-71