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. Author manuscript; available in PMC: 2015 Feb 7.
Published in final edited form as: N Engl J Med. 2014 Jul 16;371(6):507–518. doi: 10.1056/NEJMoa1312625

Figure 1. Clinical Features of Stimulator of Interferon Genes (STING)–Associated Vasculopathy with Onset in Infancy (SAVI).

Figure 1

Panel A shows the typical facial distribution of telangiectatic lesions on the nose and cheeks of Patient 1, who has SAVI. Panel B shows violaceous, scaling, atrophic plaques on the hands of Patient 6. Panel C shows histologic features of vascular inflammation in a skin-biopsy sample from a clinically involved area depicting a dense neutrophilic infiltrate with karyorrhexis throughout the vessel wall (hematoxylin and eosin); fibrin deposits are seen in the lumen of a severely damaged vessel. In Panel D, a high-resolution computed tomographic image of the lung of Patient 5 shows interstitial lung disease.