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. 2014 Sep 25;5:363. doi: 10.3389/fphys.2014.00363

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Copyright © 2014 Lovett, Chu, Wang, Ratcliffe and Baker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of NTT-MMP-2 in transgenic hearts. Immunohistochemical staining for the eGFP epitope tag present on the NTT-MMP-2 transgene. Pseudo-color enhanced immunohistochemistry of wild type (A) and transgenic (B,C) ventricular sections (400× original magnification). NTT-MMP-2 is present within mitochondria, particularly within subsarcolemmal mitochondria (indicated by arrows in B) and localizes to clusters in register with the Z-line (arrow in C). No NTT-MMP-2 staining pattern was evident in wild type hearts. Intracellular NTT is much less abundant that the FL-MMP-2 isoform, therefore, pseudo-color enhancement was used to improve contrast and to visualize the subcellular localization.