Table 1.
Gene name | Odontogenic, ameloblast-associated | Follicular dendritic cell secreted protein | Amelotin | Secretory calcium-binding phosphoprotein, rich in proline and glutamine |
---|---|---|---|---|
Abbreviation and alternate designations | ODAM (APin) | FDCSP (C4orf7; human) | AMTN | SCPPPQ1 (Gm17660; mouse) |
Genomic organization | 12 exons | 5 exons | 9 exons | 10 exons |
Protein characteristics | 28.3 kDa, pI 4.83 | 8.0 kDa, pI 4.46 | 20.4 kDa, pI 5.88 | 8.3 kDa, pI 4.68 |
PQ rich | P rich | PLTQG rich | PL rich | |
P-Ser, p-Thr | P-Ser, p-Thr | P-Ser, p-Thr, p-Tyr | P-Ser | |
O-gly | O-gly | O-gly | ||
Predominant expression | Maturation ameloblasts, junctional epithelium | Tonsils, lymph nodes, junctional epithelium | Maturation ameloblasts, junctional epithelium | Maturation stage ameloblasts |
Nasal and salivary glands, oral epithelial tumors | ||||
Possible functions | Multifunctional matricellular protein, Regulation of MMP-20 | Regulation of inflammation in the JE | Induction of mineralization, cell attachment | Unknown |
Note that phosphorylations of serine (p-Ser), threonine (p-Thr), and tyrosine (p-Tyr) as well as O-glycosylations are predicted in silico, not experimentally proven.