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. 2014 Sep 25;5:371. doi: 10.3389/fphys.2014.00371

Table 1.

Summary of genes of interest, their designation, genomic organization, protein characteristics expression profile, and possible functions.

Gene name Odontogenic, ameloblast-associated Follicular dendritic cell secreted protein Amelotin Secretory calcium-binding phosphoprotein, rich in proline and glutamine
Abbreviation and alternate designations ODAM (APin) FDCSP (C4orf7; human) AMTN SCPPPQ1 (Gm17660; mouse)
Genomic organization 12 exons 5 exons 9 exons 10 exons
Protein characteristics 28.3 kDa, pI 4.83 8.0 kDa, pI 4.46 20.4 kDa, pI 5.88 8.3 kDa, pI 4.68
PQ rich P rich PLTQG rich PL rich
P-Ser, p-Thr P-Ser, p-Thr P-Ser, p-Thr, p-Tyr P-Ser
O-gly O-gly O-gly
Predominant expression Maturation ameloblasts, junctional epithelium Tonsils, lymph nodes, junctional epithelium Maturation ameloblasts, junctional epithelium Maturation stage ameloblasts
Nasal and salivary glands, oral epithelial tumors
Possible functions Multifunctional matricellular protein, Regulation of MMP-20 Regulation of inflammation in the JE Induction of mineralization, cell attachment Unknown

Note that phosphorylations of serine (p-Ser), threonine (p-Thr), and tyrosine (p-Tyr) as well as O-glycosylations are predicted in silico, not experimentally proven.