Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Sep 25;4:138. doi: 10.3389/fcimb.2014.00138

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Guimarães, Toledo, Ferreira, Straus and Takahashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Fungal and mammal GSLs biosynthetic pathways and potential targets for new antifungal therapies. The scheme displays the biosynthetic pathways of fungal GIPCs (left), fungal GlcCer (center), and mammalian GSLs (right). The red arrows indicates the biosynthetic step where the inhibition by AbA and P4/analogs occurs, the red dashed boxes in the glycosphingolipid biosynthetic pathway indicate potential targets for the development of new antifungal therapies. LCB, long chain base; FA, fatty acid; IPC, inositol phosphorylceramide; MIPC, mannosylinositol phosphorylceramide; GIPC, glycosylinositol phosphorylceramide; AbA, Aureobasidin A; P4, D-threo-1-phenyl-2-palmitoyl-3-pyrrolidinopropanol.