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. 2014 Sep 25;8:284. doi: 10.3389/fncel.2014.00284

Figure 5.

Figure 5

Splenic CD4+ regulatory T cells increase with age in MCAO mice while CD8+ regulatory T cells are increased by RTL1000 treatment. Spleens were harvested 96 h after MCAO and immunophenotyped by flow cytometry. CD4+ regulatory T cells were gated on CD4+ positive splenocytes and determined by Foxp3 expression compared to isotype (A). Values represent mean numbers (±s.e.m.) of 5 young mice from each treatment group, 4 older vehicle and 7 older RTL mice. CD8+ regulatory T cells were gated on the CD8+CD122+ subset and determined by IL-10 expression compared to isotype (B). Values represent mean numbers (±s.e.m.) of 5 young mice from each treatment group, 3 older vehicle and 5 older RTL mice. * indicates p < 0.05.