Table 4.

Cell types in the spleen.

	8-week-old mice		16-month-old mice
Cell type	Vehicle	RTL1000	Vehicle	RTL1000
Total CD3+ T cells	34.2 ± 1.6	27.7 ± 1.8*	21.0 ± 2.1##	18.4 ± 0.7###
CD4+ T cells	18.7 ± 1.2	15.1 ± 0.6*	12.8 ± 0.8##	9.8 ± 0.3**###
CD8+ T cells	13.9 ± 0.9	9.9 ± 1.2*	10.0 ± 1.0#	10.0 ± 0.9
CD11b+ myeloid cells	4.9 ± 0.4	3.6 ± 0.4*	3.2 ± 0.2##	3.5 ± 0.2
CD11b+Ly6G+ neutrophils	4.9 ± 0.4	3.8 ± 0.5	4.7 ± 0.3	4.3 ± 0.3
CD11b+Ly6C+ monocytes	3.5 ± 0.3	2.2 ± 0.4*	2.6 ± 0.3#	2.9 ± 0.2
CD11c+ dendritic cells	1.6 ± 0.1	1.8 ± 0.2	1.3 ± 0.1	1.9 ± 0.2
CD19+ B cells	42.8 ± 2.7	53.7 ± 2.0*	59.0 ± 1.5##	62.3 ± 1.5##

^*indicates significance compare to vehicle ^*p ≤ 0.05; ^**p ≤ 0.01.

^#indicates significance compared to 8-week-old mice ^#p ≤ 0.05; ^##p ≤ 0.01; ^###p ≤ 0.001.