Table 6.

Activation/migration markers on T cells.

Cell type/Marker	8-week-old mice		16-month-old mice
	Vehicle	RTL1000	Vehicle	RTL1000
CD4+CD69+	12.7 ± 1.1	12.3 ± 0.4	2.4 ± 0.4###	1.8 ± 0.1###
CD8+CD69+	4.1 ± 0.6	3.2 ± 0.2	2.4 ± 0.6	1.4 ± 0.1###
CD4+CD44+	25.5 ± 0.8	30.1 ± 1.5*	41.5 ± 1.7###	43.3 ± 1.9###
CD8+CD44+	22.3 ± 1.3	25.1 ± 1.3	48.5 ± 1.7###	51.0 ± 3.0###
CD3+CCR5+	8.5 ± 1.3	9.3 ± 0.4	8.6 ± 1.3	8.4 ± 0.4

^*indicates significance compare to vehicle ^*p ≤ 0.05.

^#indicates significance compared to 8-week-old mice ^###p ≤ 0.001.