Table 1. HS rat SNPs that pass the region-wide significance threshold for fasting glucose and/or Tpcn2 expression levels.
| SNP location (bp) | Gene/functional location | Trait (−log P) | Variant | Founder strain(s) with variant | Amino acid change (Polyphen and SIFT predictions) |
|---|---|---|---|---|---|
| 205,653,821 | Rmt1/intron | Fasting glucose (3.62) | T to C | ACI, BUF, M520, MR, WKY, WN | NA |
| Tpcn2 expression (6.58) | |||||
| 205,715,459 | Tpcn2/exon | Fasting glucose (3.35) | G to A | F344 | P to L (benign/tolerated) |
| Tpcn2 expression (6.17) | |||||
| 205,898,738 | Cpt1a/exon | Tpcn2 expression (4.90) | G to A | ACI, BUF, M520, MR, WN | V to I (benign/tolerated) |
| 206,242,238 | RGD1311946/exon | Tpcn2 expression (3.69) | G to A | F344 | A to T (unknown/tolerated) |
| 206,726,856 | Gpr152/exon | Tpcn2 expression (4.43) | C to T | F344 | Q to * (unknown/unknown) |
*
indicates a stop codon.