Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The first allosteric modulators with clinical success were benzodiazepines (BZDs), GABAA PAMs. The generic BZD core 1 and important medications 2 (Valium) and the tricylic analog 3 (Xanax) are shown. Also shown are structures of the two marketed GPCR allosteric modulators: cinacalcet (4), a calcium sensing receptor PAM, and maraviroc (5), a CCR5 NAM.
