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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Pharm Sci. 2014 Jul 14;103(10):3033–3042. doi: 10.1002/jps.24074

Scheme 2.

Scheme 2

A. Hydrazide can be further derivatized by reaction with sulfonyl chloride to incorporate a UV or fluorescence or affinity (e.g., biotin) tag. B. Hydrazide can be reversibly bound to aldehydefunctionalized resin for affinity enrichment by formation of hydrazone.