Table 1.

VEGF-A and VEGFR3 SNPs assessed in this study

Gene	Description	Nucleotide position relative to start codona	Region/amino acid change	Minor allele frequency, Caucasians, public datab (%)	SNP ID	References
VEGF-A	−2578 C/A	−2056	Upstream of VEGF-A	41	rs699947	[8, 18, 19]
VEGF-A	−1154 G/A	−614	Promoter	33	rs1570360	[8, 19]
VEGFR3	2670 C>G	2670	Exon 19, H890Q	40	rs448012	[10]
VEGFR3	3971 G>T	3971	Exon 30, R1324L	9	rs307821	[10]
VEGFR3	1480 A>G	1480	Exon 11, T484A	8	rs307826	[10]

Prognostic markers provide information about a patient’s outcome, independent of therapy. Predictive markers provide information about response to a therapy. Adjustments for multiple testing were not always used in these studies

SNP Single-nucleotide polymorphism, VEGF vascular endothelial growth factor, VEGFR VEGF receptor

^aNCBI transcript numbers used for calculating position relative to the start codon are VEGF-A NM_001025366, VEGFR3 NM_182925

^bMinor allele frequencies are from HapMap, dbSNP, or published data