Table 1. Macaque infections.
Macaque # | Macaque ID | Menstrual cycle day at 1st SHIV RNA+ | Graph of menstrual cycle data, reference | RLD virus challenges/week | Progesterone data/week | RLD virus challenges to infection | Virus stock, dose |
---|---|---|---|---|---|---|---|
1 | POh2 | 1 | Fig. 1 | 1 | 2 | 6 | N-50 |
2 | 96PO25 | 26 | 1 | 1 | 7 | N-50 | |
3 | A1 | 15 | 2 | 2 | 7 | N-50 | |
4 | A2 | 15 | 2 | 2 | 9 | N-50 | |
5 | A3 | 12 | 2 | 2 | 11 | N-50 | |
6 | A4 | 29 | 2 | 2 | 20 | N-50 | |
7 | PVC2 | 4 | 2 | 1 | 7 | N-50 | |
8 | PZA2 | NI | 2 | 1 | >14 | N-50 | |
9 | PSd2 | 4 | 2 | 1 | 11 | N-50 | |
10 | PEG2 | 4 | 2 | 1 | 10 | N-50 | |
11 | PUG2 | NI | 2 | 1 | >14 | N-50 | |
12 | PZG2 | 4 | 2 | 1 | 6 | N-50 | |
13 | P8P | 7 | [16] | 1 | 1 | 4 | O-10 |
14 | Pct-1 | 18 | 2 | 2 | 9 | O-10 | |
15 | 96Po17 | 1 | 2 | 2 | 1 | N-50 | |
16 | Pra-2 | 4 | 2 | 2 | 3 | O-10 | |
17 | 96Po26 | 9 | 2 | 2 | 5 | N-50 | |
18 | TD6 | 1 | 2 | 1 | 6 | N-10 | |
19 | PGB2 | 1 | 2 | 2 | 2 | O-10 | |
20 | Ptd2 | 15 | 1 | 1 | 4 | O-10 | |
21 | FH3 | 10 | 2 | 2 | 2 | N-50 | |
22 | 96Po78 | 4 | 2 | 2 | 6 | N-50 | |
23 | Pde-2 | 11 | 2 | 2 | 3 | O-10 | |
24 | PMc-2 | 8 | 2 | 2 | 10 | O-10 | |
25 | PsC-2 | 8 | 2 | 2 | 2 | O-10 | |
26 | Pvr-1 | 15 | 2 | 2 | 4 | O-10 | |
27 | P8X | 1 | 1 | 1 | 2 | O-10 | |
28 | Pya-2 | 4 | 2 | 2 | 2 | O-10 | |
29 | Pzu-1 | 8 | 2 | 2 | 5 | O-10 | |
30 | 303 | 1 | 1 | 1 | 14 | O-10 | |
31 | FF2 | 8 | 1 | 1 | 3 | O-10 | |
32 | PQB1 | 1 | [12] | 1 | 1 | 1 | N-50 |
33 | PRW | 15 | 1 | 1 | 2 | N-50 | |
34 | FJ24 | 15 | 1 | 1 | 5 | N-50 | |
35 | FJ25 | 15 | 1 | 1 | 4 | N-50 | |
36 | DL82 | 29 | 1 | 1 | 3 | N-50 | |
37 | Ppi | 8 | 1 | 1 | 10 | N-50 | |
38 | BB336 | NI | [14] | 1 | 1 | >14 | N-50 |
39 | BB401 | 8 | 1 | 1 | 1 | N-50 | |
40 | BB966 | 14 | 1 | 1 | 11 | N-50 | |
41 | BB925 | 21 | 1 | 1 | 7 | N-50 | |
42 | BB588 | 1 | 1 | 1 | 3 | N-50 | |
43 | BB432 | 1 | 1 | 1 | 4 | N-50 | |
44 | PRG2 | 1 | [4] | 2 | 2 | 4 | N-10 |
45 | CN19 | 10 | 2 | 2 | 8 | N-10 | |
46 | PYH2 | 8 | 2 | 2 | 9 | N-10 |
The table lists time point of first detected plasma viremia in the menstrual cycle of 46 female pigtail macaques, exposed to SHIVSF162P3 by vaginal route using the repeat-low dose (RLD) challenge approach. They received one or two challenges/week, for up to 14 or 20 challenges, using a dose of 10 – 50 TCID-50. The number of virus challenges required for infection is listed, using an eclipse phase of 7 days to determine the infecting challenge. Abbreviation and symbols used: NI=not infected, >14= maximal number of 14 challenges was administered, but the animal remained uninfected; O-10=old virus stock, given at 10 Tissue culture infectious doses (TCID-50); N=new virus stock; ID=identification; RNA+ = above 49 viral RNA copies/ml of plasma.