Figure 6.
Correlating focal disruption of the foveal cone mosaic with SD-OCT and AOSLO. Subjects WW_0923, Case 6 (A-C) and KS_0931, Case 7 (D-F) both showed similar presentation on research imaging, despite variable initial clinical presentation. Focal disruptions were seen on SD-OCT (A, D), best characterized as an outer lamellar defect that included the EZ and IZ bands. Vertical arrows indicate the area subtended by the AOSLO montages (B, E). The AOSLO images are displayed on a logarithmic scale and each shows a distinct hyporeflective lesion. In the retinal areas immediately adjacent to the focal lesion, the cone mosaic was contiguous and of normal density, highlighting the truly focal nature of these defects. The dashed black line on each AOSLO image indicates the location of the corresponding SD-OCT image. SD-OCT en face images of the EZ band integrity (C, F) show good agreement in the size and shape of the lesion as assessed with the 2 different imaging modalities. Scale bars = 100 μm.