Table 2.
Regression of clinical and metabolic phenotypes on AIF-1 expression
| AIF-1 1 | AIF-1 2 | |||
|---|---|---|---|---|
|
Regressor |
r -value |
p value |
Partial r-value |
p value |
|
Age (years, n = 96) |
0.056 |
0.59 |
- |
- |
|
BMI (kg/m
2
, n = 96) |
0.44 |
<0.001 |
- |
- |
|
KITT (rate constants, n = 46)
3
|
−0.378 |
0.0096 |
−0.396 |
0.017 |
|
Adiponectin (μg/ml, n = 37)
4
|
−0.375 |
0.022 |
−0.334 |
0.023 |
|
Adipose morphology (delta, n = 96)
5
|
0.274 |
0.0068 |
0.148 |
0.13 |
|
Fat cell volume (n = 96)
6
|
0.456 |
<0.0001 |
0.396 |
0.0041 |
| Log HOMA (n = 93) 7 | 0.497 | <0.0001 | 0.369 | 0.0042 |
1Simple regression. 2Multiple regression with BMI together with one other variable at a time as independent variables. In the multiple regression, BMI became non-significant when examined together with KITT, fat cell volume or HOMA (partial r between 0.04 and 0.18). However it remained significant together with adiponectin (partial r = 0.44; p = 0.004) 3Insulin tolerance test was performed in patients after an overnight fast. Insulin was rapidly injected intravenously. After 2.5, 5, 7.5, 10, 15, 20, 25 and 30 min’s, blood glucose levels were determined and plotted in a semilogaritmic graph depicting blood glucose decrease along time. The rate constant (k) derived from this plot represented the intravenous insulin tolerance (KITT). 4Serum levels of adiponectin were measured using a RIA method. 5The relationship between mean adipocyte volume and total body fat determines adipocyte morphology. Delta is the difference between observed adipocyte volume in the present investigation and the expected volume (as obtained from the curve fit) at the corresponding level of total body fat mass were calculated separately for each woman. The morphology values are quantitative: a larger absolute positive or negative value (delta) reflects more pronounced hypertrophy or hyperplasia, respectively, compared with a small value, see Morphology in methods section for details. 6Adipocytes were isolated from adipose tissue by collagenase digestion as previously described and mean fat cell size determined as described in reference [21]. 7The homeostasis model assessment for insulin resistance (HOMAIR) was calculated as fasting serum insulin (μU/ml) x fasting plasma glucose (mmol/L)/22.5.