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Under substitution with at least 0.8 mg/d folic acid, AMH concentrations in IVF/ICSI patients with a homozygous MTHFR 677TT mutation are significantly higher compared to heterozygous MTHFR 677CT patients (* p < 0.04) or wild-type MTHFR 677CC patients (** p < 0.002). This is particularly remarkable in view of the fact that there were no differences in the total number of retrieved oocytes between the different MTHFR 677 genotypes (from 37).
