Fig. 6.

 The significant (p < 0.001) correlation between AMH concentrations and number of retrieved oocytes following controlled ovarian hyperstimulation and follicular puncture is also found in individual evaluations of the three MTHFR 677 genotypes. However, the correlation line for IVF/ICSI carriers of the homozygous MTHFR 677TT mutation (red line) shifts downwards, i.e. towards lower oocyte numbers. Patients with AMH concentrations of 4 ng/ml and the MTHFR 677TT genotype were found to have an average of 13 oocytes (arrow with broken line on the left), while carriers of the wild-type MTHFR 677CC genotype on the same stimulation regime had an average of 16 oocytes (arrow with continuous line on the left). This is clinically relevant because AMH concentrations in carriers of the homozygous MTHFR 677TT mutation could be overestimated by around 20 %, at least with regard to expected oocyte numbers (modified from 37).