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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Prostate. 2014 Aug 29;74(15):1506–1520. doi: 10.1002/pros.22868

Figure 1. Deletion of Apc induced β-catenin and Axin2 expression.

Figure 1

(a) Timeline of tamoxifen treatment for the Tam-only group. (b) Apc-allele-specific PCR on tissue from control mice without Cre expression - Nkx3.1CreERT+/+;Apcflox/flox (Apcflox) or Nkx3.1CreERTtg/+;Apcflox/flox (ApccKO) mice. DLP: dorsolateral prostate; VP: ventral prostate; AP: anterior prostate; SV: seminal vesicle. (c) Apc and β-catenin IHC on anterior prostate tissue from Apcflox or ApccKO mice. (d) Apc qualitative RT-PCR on anterior prostate tissue from Apcflox or ApccKO mice. (e) Quantitative RT-PCR on anterior prostate tissue from Apcflox or ApccKO mice; * p <0.0003. (f) Confocal imaging of Nkx3.1CreERTmT/mG anterior prostate. (g) Quantification of GFP-positive cells from PBCre4mT/mG (left bar) or Nkx3.1CreERTmT/mG (remaining bars) anterior prostate. * p <0.05.